Malignant tumors are insidious in onset and difficult to diagnose at an early stage, and the sensitivity and specificity of serological markers currently in clinical use still need to be improved. Mass spectrometry flow (CyTOF), as a newly developed technique to detect the composition and number of immune cells, can obtain high-dimensional information on the composition, phenotype and function of peripheral blood immune cells. Evaluation of peripheral immune status using mass spectrometry flow technology is expected to provide a novel tool for early screening and early diagnosis of tumors.

RNAs can regulate inflammation onset, progression, and regression by altering expression and localization, and are key regulators in the inflammatory process; however, the use of ‍RNA‍ as a biomarker for the in vivo optical imaging of inflammation has not yet been demonstrated. Recently, a research team from the National Center for Nanoscience realized real-time dynamic imaging and early diagnosis of inflammation-related mRNAs in vivo. The related results were published in Nature Biomedical Engineering, and the title of the paper is “Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon”.

Intracardiac ultrasound (ICE) is an emerging echocardiographic diagnostic technology, which places a catheter equipped with a micro-ultrasound transducer probe inside the cardiac chambers through a vascular pathway, transmits and receives high-frequency ultrasound signals, and realizes real-time imaging of cardiac anatomy. Currently, ICE has been applied to a variety of procedures, such as radiofrequency ablation of atrial fibrillation, left auricle occlusion, atrial septal defect occlusion, mitral valvuloplasty, endomyocardial biopsy, and so on.

In recent years, the State Drug Administration to fully implement the Party Central Committee and State Council to deepen the medical device review and approval system reform requirements, and actively promote innovative medical devices, national key research and development programs and major scientific and technological special medical devices on the market, to promote industrial innovation and high-quality development, to better meet the needs of patients' health.

A team of researchers from the Australian National University found that proteins called guanylate-binding proteins (GBPs) mediate pathogens' selective activation of inflammatory vesicles to trigger host defenses and innate immune responses, said a recent study published in Nature Communications.

In recent years, the prevalence of hypertension has been increasing year by year. Renal artery sympathetic nerve radiofrequency ablation (RDN) is an effective treatment for hypertension and is expected to become the preferred option and a powerful supplement to drug combination therapy by virtue of the advantages of higher safety and better antihypertensive effect. Meanwhile, the clinical application of RDN devices is in strong demand, and the potential market space is vast.

The National Technical Committee for Standardization of Biological Evaluation of Medical Devices (SAC/TC248, hereinafter referred to as TC248) is responsible for the formulation and revision of national standards and industry standards for biological evaluation of medical devices in China, and participates in the standardization work of its counterpart in the International Organization for Standardization (ISO)-Technical Committee for Biological and Clinical Evaluation of Medical Devices (ISO/TC194) on behalf of China. TC248 has been in preparation since the beginning of 1995, and the secretariat relies on Shandong Institute of Medical Devices and Pharmaceutical Packaging Inspection. In the process of preparation, TC248 closely follow the pace of international standards, comprehensively carry out the standardization work in the field of biological evaluation of medical devices. 2001, the first committee of TC248 was formally established.

Most vaccines require multiple injections to achieve full immunity. Recently, a team of researchers at the Massachusetts Institute of Technology (MIT) developed a novel vaccine delivery platform that allows a single injection to achieve the same effect as multiple previous vaccinations. The results were published in Science Advances in a paper titled “Experimental and computational understanding of pulsatile release mechanism from Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles”.

The Guiding Opinions on Further Improving and Implementing Active Reproductive Support Measures issued by 17 departments, including the National Health and Health Commission and the National Development and Reform Commission, were published on the 16th of October, promoting the in-depth implementation of the policy that one couple can have three children. The Guidelines consider marriage, childbirth, parenting and education as a whole, and accelerate the establishment of a system of active childbirth support policies through policies in finance, taxation, insurance, education, housing, employment and other related areas, so as to provide strong support for promoting the realization of an appropriate level of fertility and long-term balanced development of the population.

As a transcription factor with a wide range of roles, c-Myc is a key protein in the regulation of cell fate, but it is also recognized as one of the targets that are difficult to become a drug. Therefore, the regulation and intervention means of c-Myc has been one of the frontier and hotspot directions of international competition, and the relevant targeting research will receive wide attention and cause further breakthroughs in the field of stem cell, tumor and drug development once important progress is made.