NEWS CENTER
2022-09-06
Scientists develop new vaccine delivery platform
Most vaccines require multiple injections to achieve full immunity. Recently, a team of researchers at the Massachusetts Institute of Technology (MIT) developed a novel vaccine delivery platform that allows a single injection to achieve the same effect as multiple previous vaccinations. The results were published in Science Advances in a paper titled “Experimental and computational understanding of pulsatile release mechanism from Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles”.
In the study, a biodegradable core-shell microparticle was designed to encapsulate vaccine components to enhance effectiveness and adhesion, and to release vaccine components at predetermined time intervals. Polylactic acid-hydroxyacetic acid copolymer (PLGA) was chosen as the material for the study, and core-shell particles of arbitrary shapes or sizes were produced by the SEAL (StampEd Assembly of polymer Layers) sealed assembly technique. It was found that particle size and shape had little effect on drug release kinetics, but rather the PLGA particles released their payload at different times depending on the differences in polymer composition and the chemical groups attached to the polymer ends. As a result, the team developed a computational model that can predict how specific particles will degrade in vivo based on different design parameters.
This research contributes to the development and design of self-reinforcing vaccines that require only a single injection. This single-injection strategy not only helps to improve the compliance of the vaccinators, but also helps to enhance the immune response effect of the vaccine, which is expected to play a unique role in scenarios such as tumor immunotherapy and drug delivery.
Source: China Center for Biotechnology Development
Note: This research result is extracted from the journal Science Advances, the content of the article does not represent the views and positions of this website, and is for reference only.
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