NEWS CENTER
2022-09-30
Chinese scientists realize real-time dynamic imaging and early diagnosis of inflammation-related mRNAs in vivo
Source: China Center for Biotechnology Development
RNAs can regulate inflammation onset, progression, and regression by altering expression and localization, and are key regulators in the inflammatory process; however, the use of RNA as a biomarker for the in vivo optical imaging of inflammation has not yet been demonstrated. Recently, a research team from the National Center for Nanoscience realized real-time dynamic imaging and early diagnosis of inflammation-related mRNAs in vivo. The related results were published in Nature Biomedical Engineering, and the title of the paper is “Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon”.
The research team designed and constructed an enzyme-triggered molecular beacon-based inflammation cell-specific signal amplification method to achieve high signal-to-background ratio imaging of inflammation-associated mRNA through spatially selective amplification of inflammation-associated RNA imaging signals. This study evaluated the sensitivity and tissue specificity of engineered molecular beacons targeting interleukin-6 (IL-6) mRNA in live mice by detecting acute inflammation in mouse paws and drug-induced inflammation in the liver. The study demonstrates that this enzymatic amplification strategy allows for specific and sensitive imaging of other disease-related RNAs in vivo.
This study provides a new method for highly sensitive imaging of inflammation-associated mRNA, which is useful for real-time monitoring of inflammation and diagnosis of drug-induced toxicity, and is expected to be applied to the early diagnosis of inflammation-associated disorders and real-time evaluation of therapeutic processes.
Note: This research result is extracted from the journal Nature Biomedical Engineering, the content of the article does not represent the views and positions of this website, and is for reference only.
You may also be interested in
Copyright © 2023 Tianyi Medical All Rights Reserved. | SEO | Powered by www.300.cn
Copyright © 2023 Tianyi Medical All Rights Reserved.
This website contains product information aimed at a wide audience and may contain product details or information that is not accessible or invalid in your country. Please note that we are not responsible for access to such information that may not comply with any legal process, regulation, registration or use in your country.
This website contains product information aimed at a wide audience and may contain product details or information that is not accessible or invalid in your country. Please note that we are not responsible for access to such information that may not comply with any legal process, regulation, registration or use in your country.